Regulation of tooth mineralization

Across TCGA patient cohorts, RNA activity of the Regulation of tooth mineralization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINB9, SIPA1, and AGAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tooth mineralization activity versus SERPINB9 in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SERPINB9 →	-0.447	-0.079	<.001	<.001	3	5
BRCA	SIPA1 →	-0.193	-0.079	<.001	.001	3	5
BRCA	AGAP2 →	-0.327	-0.079	<.001	<.001	3	5
BRCA	DOK2 →	-0.420	-0.082	<.001	<.001	3	5
UCEC	EFNA1 →	+0.723	+0.098	.001	<.001	3	5
LSCC	CARD9_S460 →	-0.361	-0.060	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070170 vs SERPINB9 — LSCC

Explore this scatter interactively →