Regulation of tooth mineralization

Across TCGA patient cohorts, RNA activity of the Regulation of tooth mineralization pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNMB4, DMTN, and CFTR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tooth mineralization activity versus KCNMB4 in PDAC (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KCNMB4 →	-0.467	-0.572	<.001	<.001	3	4
LUAD	DMTN →	+0.633	+0.552	<.001	<.001	3	3
PDAC	CFTR →	+1.261	+0.766	<.001	<.001	3	3
LUAD	ATP1A1 →	+0.516	+0.543	.001	<.001	3	3
LUAD	SDK1-AS1 →	+0.873	+0.513	<.001	.001	3	3
PDAC	C2CD4B →	+1.262	+0.833	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070170 vs KCNMB4 — PDAC

Explore this scatter interactively →