Regulation of tooth mineralization

Across TCGA cell cohorts, RNA activity of the Regulation of tooth mineralization pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, B3GNT5, and ULK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R12A grouped by Regulation of tooth mineralization-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPP1R12A →	-0.703	-0.959	.003	.004	3	4
OVARY	B3GNT5 →	-1.776	-1.323	.002	.001	3	4
LUNG_NSCLC_LUAD	ULK3 →	+0.705	+0.917	.005	.004	3	4
KIDNEY	CACUL1 →	-0.764	-1.050	<.001	.001	3	4
KIDNEY	PPP1CB →	-0.572	-0.982	.003	.003	3	4
LARGE_INTESTINE	TPI1 →	-0.495	-0.706	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R12A by Regulation of tooth mineralization activity — KIDNEY

Explore this box plot interactively →