Regulation of tooth mineralization

Across TCGA cell cohorts, RNA activity of the Regulation of tooth mineralization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GYG1, C1orf116, and DXO, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tooth mineralization activity versus GYG1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GYG1 →	-1.423	-2.284	<.001	<.001	3	3
STOMACH	C1orf116 →	+3.160	+1.873	.005	<.001	3	3
STOMACH	DXO →	-0.713	-1.873	<.001	<.001	3	3
LUNG_NSCLC_LUAD	GLA →	-1.498	-1.317	.002	.001	3	2
LUNG_NSCLC_LUAD	GPR132 →	+1.525	+1.671	.007	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	TAS2R42 →	+0.035	+2.089	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070170 vs GYG1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →