Positive regulation of biomineral tissue development

Across TCGA cell cohorts, RNA activity of the Positive regulation of biomineral tissue development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBR5, GINM1, and AREG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBR5 grouped by Positive regulation of biomineral tissue development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UBR5 →	-1.082	-1.107	<.001	.003	3	3
OVARY	GINM1 →	-0.975	-1.112	<.001	.004	3	3
LUNG_NSCLC_LUSC	AREG →	+4.184	+0.319	.002	.001	3	2
CNS	ARHGAP6 →	-0.777	-0.755	.002	.005	3	2
CNS	MON2 →	-0.379	-0.615	.004	.004	2	3
SOFT_TISSUE	PPIL2 →	-0.676	-1.236	.005	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBR5 by Positive regulation of biomineral tissue development activity — SOFT_TISSUE

Explore this box plot interactively →