Enamel mineralization

Across TCGA patient cohorts, RNA activity of the Enamel mineralization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAIAP2L1_S331, ABCC5_S505, and DTNBP1_S300, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enamel mineralization activity versus BAIAP2L1_S331 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BAIAP2L1_S331 →	+0.711	+0.080	<.001	<.001	3	4
LSCC	ABCC5_S505 →	+1.409	+0.098	.003	<.001	3	4
LUAD	DTNBP1_S300 →	+1.052	+0.086	<.001	.002	3	4
LSCC	POF1B_S413 →	+0.782	+0.063	.001	.002	3	4
PDAC	DYNC2I2 →	-0.940	-0.135	.003	.006	3	4
GBM	SELENOO →	+0.207	+0.084	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070166 vs BAIAP2L1_S331 — HNSC

Explore this scatter interactively →