Enamel mineralization

Across TCGA cell cohorts, RNA activity of the Enamel mineralization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FADS1, LMNA, and ZNF202, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FADS1 grouped by Enamel mineralization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FADS1 →	+2.021	+1.549	.007	.001	3	5
LUNG_NSCLC_LUSC	LMNA →	-1.295	-1.703	<.001	<.001	3	5
LUNG_SCLC	ZNF202 →	+0.791	+1.020	.005	.004	3	4
SKIN	DENND5B →	+0.763	+1.350	.001	<.001	3	4
SOFT_TISSUE	ME3 →	-2.816	-1.299	.001	.004	3	4
BONE	EPM2AIP1 →	+1.047	+1.638	.006	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FADS1 by Enamel mineralization activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →