Enamel mineralization

Across TCGA cell cohorts, RNA activity of the Enamel mineralization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR83, SMAD5, and DPPA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR83 grouped by Enamel mineralization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WDR83 →	-0.093	-0.358	.001	.003	3	4
STOMACH	SMAD5 →	+0.165	+0.256	.003	.003	3	4
KIDNEY	DPPA4 →	+0.227	+0.451	.004	.002	3	3
LUNG_NSCLC_LUSC	CREG1 →	+0.316	+0.393	<.001	<.001	3	3
LUNG_NSCLC_LUSC	ANXA9 →	-0.545	-0.372	<.001	<.001	3	3
LUNG_NSCLC_LUSC	CAMK4 →	-0.181	-0.362	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR83 by Enamel mineralization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →