Regulation of adiponectin secretion

Across TCGA patient cohorts, RNA activity of the Regulation of adiponectin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02154, ANTXR2, and FAM114A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adiponectin secretion activity versus LINC02154 in LSCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LINC02154 →	+0.817	+0.766	.005	.001	3	5
GBM	ANTXR2 →	+0.556	+0.455	<.001	.001	3	5
GBM	FAM114A1 →	+0.817	+0.518	<.001	.001	3	5
LSCC	RAB11FIP5 →	+0.660	+0.916	<.001	<.001	3	4
BRCA	CERCAM →	+0.772	+0.722	<.001	<.001	3	4
LSCC	TMEM92-AS1 →	+0.448	+0.548	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070163 vs LINC02154 — LSCC

Explore this scatter interactively →