Regulation of adiponectin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of adiponectin secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP5, IL1B, and RAB11FIP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB11FIP5 grouped by Regulation of adiponectin secretion-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAB11FIP5 →	-0.376	-1.483	.004	.006	3	9
OVARY	IL1B →	-0.383	-1.624	<.001	<.001	3	9
CNS	RAB11FIP3 →	-0.298	-1.541	.001	<.001	2	9
LUNG_NSCLC_LUAD	C1QTNF3 →	-0.141	-1.095	<.001	<.001	3	6
BLOOD_Leukemia	ACCS →	-0.210	-0.996	.007	.004	3	6
LUNG_NSCLC_LUSC	IRF1 →	-0.233	-1.252	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB11FIP5 by Regulation of adiponectin secretion activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →