Regulation of adiponectin secretion

Across TCGA cell cohorts, RNA activity of the Regulation of adiponectin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNKP, ZNF155, and ZNF222, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNKP grouped by Regulation of adiponectin secretion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PNKP →	+0.857	+1.189	.005	.003	3	6
UPPER_AERODIGESTIVE_TRACT	ZNF155 →	+1.191	+1.569	.003	.001	3	5
LUNG_SCLC	ZNF222 →	+0.746	+1.107	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SNAPC4 →	+1.106	+1.442	.005	.003	3	4
UPPER_AERODIGESTIVE_TRACT	WDR59 →	+1.586	+1.669	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	USB1 →	+0.910	+1.243	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNKP by Regulation of adiponectin secretion activity — LUNG_SCLC

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