Synaptic vesicle budding

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle budding pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP3B2_S272, CACNA2D1, and AP3M2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle budding activity versus AP3B2_S272 in UCEC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP3B2_S272 →	-1.270	-0.078	<.001	.001	3	7
UCEC	CACNA2D1 →	-0.515	-0.046	<.001	.009	3	5
LSCC	AP3M2 →	+0.228	+0.059	.001	<.001	3	5
GBM	SRPK2 →	+0.306	+0.080	.001	<.001	3	5
COAD	SIGIRR →	+0.413	+0.052	.001	<.001	3	4
GBM	VCL_S579 →	-0.703	-0.090	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070142 vs AP3B2_S272 — UCEC

Explore this scatter interactively →