Synaptic vesicle budding

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN1, NFE2, and DVL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle budding activity versus TSPAN1 in LARGE_INTESTINE (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TSPAN1 →	-1.853	-0.935	.004	.001	3	5
OVARY	NFE2 →	-0.922	-1.568	.007	<.001	3	5
STOMACH	DVL1 →	+0.624	+1.251	.002	.001	3	4
STOMACH	KLF16 →	+1.135	+1.505	.002	.001	3	4
STOMACH	ARL5A →	+0.721	+1.066	.008	.009	3	4
STOMACH	FAM174C →	+0.635	+1.384	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070142 vs TSPAN1 — LARGE_INTESTINE

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