Response to UV-A

Across TCGA patient cohorts, RNA activity of the Response to UV-A pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP2, MMP9, and ADAM19, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-A activity versus MMP2 in UVM (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	MMP2 →	+2.665	+0.064	<.001	<.001	3	26
BLCA	MMP9 →	+2.084	+0.072	<.001	<.001	3	25
BLCA	ADAM19 →	+1.422	+0.064	<.001	<.001	3	24
SCLC	POSTN →	+2.271	+0.215	<.001	<.001	3	23
SCLC	ITGAX →	+1.873	+0.231	<.001	<.001	3	23
TGCT	COL1A2 →	+2.002	+0.061	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070141 vs MMP2 — UVM

Explore this scatter interactively →