Response to UV-A

Across TCGA patient cohorts, RNA activity of the Response to UV-A pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MME, MMP2, and COL1A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-A activity versus MME in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MME →	+0.547	+0.074	.002	<.001	3	7
GBM	MMP2 →	+0.501	+0.154	<.001	<.001	3	7
LSCC	COL1A1 →	+0.756	+0.102	<.001	<.001	3	6
LSCC	ENG →	+0.292	+0.072	<.001	.002	3	6
BRCA	LBH →	+0.273	+0.054	<.001	<.001	3	6
BRCA	LGALS1 →	+0.393	+0.073	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070141 vs MME — LSCC

Explore this scatter interactively →