Response to UV-A

Across TCGA cell cohorts, RNA activity of the Response to UV-A pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCQ, CCND1, and NUDT11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCQ grouped by Response to UV-A-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRKCQ →	-1.027	-0.862	.001	.008	3	4
LUNG_NSCLC_LUAD	CCND1 →	+1.452	+1.031	<.001	<.001	3	4
LUNG_NSCLC_LUSC	NUDT11 →	-2.603	-1.228	.001	.009	3	4
BLOOD_Lymphoma	CHP1 →	+0.429	+1.576	<.001	.001	3	4
KIDNEY	PTCH2 →	-0.308	-1.020	.001	.003	3	4
SOFT_TISSUE	ARFGEF3 →	-1.912	-1.357	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCQ by Response to UV-A activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →