Response to UV-A

Across TCGA cell cohorts, RNA activity of the Response to UV-A pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPS8L2, DNAJC19, and SPRY4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV-A activity versus EPS8L2 in BLOOD_Lymphoma (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	EPS8L2 →	-1.523	-0.253	.004	.001	3	4
SKIN	DNAJC19 →	+0.471	+0.544	.003	.007	3	4
BLOOD_Leukemia	SPRY4 →	-1.704	-0.239	.002	.002	3	4
SOFT_TISSUE	EPB41L5 →	-1.443	-0.259	.002	.008	3	3
BLOOD_Myeloma	CAPRIN2 →	+1.248	+0.586	.003	.002	2	4
BLOOD_Myeloma	FGFR4 →	+1.238	+0.401	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070141 vs EPS8L2 — BLOOD_Lymphoma

Explore this scatter interactively →