tRNA aminoacylation for mitochondrial protein translation

Across TCGA patient cohorts, RNA activity of the tRNA aminoacylation for mitochondrial protein translation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP25, BCAS2, and TTF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA aminoacylation for mitochondrial protein translation activity versus UTP25 in LUAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UTP25 →	+0.264	+0.040	<.001	<.001	3	5
UCEC	BCAS2 →	+0.232	+0.102	<.001	<.001	3	4
HNSC	TTF2 →	+0.316	+0.072	<.001	.008	3	4
LSCC	ZNF318_S709 →	+0.395	+0.027	<.001	.008	3	4
GBM	FUBP1 →	+0.225	+0.040	.005	.005	3	4
BRCA	RBBP6 →	+0.214	+0.031	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070127 vs UTP25 — LUAD

Explore this scatter interactively →