tRNA aminoacylation for mitochondrial protein translation

Across TCGA patient cohorts, RNA activity of the tRNA aminoacylation for mitochondrial protein translation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PACSIN3, STS, and PLA2G7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA aminoacylation for mitochondrial protein translation activity versus PACSIN3 in OV (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PACSIN3 →	+1.130	+0.184	<.001	<.001	3	4
OV	STS →	-0.804	-0.185	<.001	<.001	3	3
OV	PLA2G7 →	-1.177	-0.141	<.001	.001	3	3
UCEC	LANCL3 →	-0.473	-0.116	<.001	<.001	3	3
PDAC	CSF2 →	-0.785	-0.075	.001	.006	2	4
OV	INTS6L →	-0.695	-0.161	.006	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070127 vs PACSIN3 — OV

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