tRNA aminoacylation for mitochondrial protein translation

Across TCGA cell cohorts, RNA activity of the tRNA aminoacylation for mitochondrial protein translation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXL2, ASPH, and TIMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXL2 grouped by tRNA aminoacylation for mitochondrial protein translation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FBXL2 →	+0.898	+0.307	.002	.001	2	5
SKIN	ASPH →	+0.879	+1.109	.005	.004	3	4
LARGE_INTESTINE	TIMP2 →	+2.696	+1.154	.007	.003	3	4
BREAST	MAP3K14 →	+0.997	+0.739	.002	.004	3	4
SOFT_TISSUE	YPEL1 →	-1.134	-1.576	.003	.001	3	3
PANCREAS	AKT2 →	-0.941	-0.274	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXL2 by tRNA aminoacylation for mitochondrial protein translation activity — PANCREAS

Explore this box plot interactively →