tRNA aminoacylation for mitochondrial protein translation

Across TCGA cell cohorts, RNA activity of the tRNA aminoacylation for mitochondrial protein translation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIF1L, SLC11A2, and SLC27A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA aminoacylation for mitochondrial protein translation activity versus AIF1L in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AIF1L →	+2.939	+0.485	.009	.004	3	6
PANCREAS	SLC11A2 →	+0.792	+0.230	.006	.002	3	5
PANCREAS	SLC27A2 →	+2.025	+0.340	.009	.001	3	5
OVARY	PELI1 →	+1.637	+0.306	<.001	<.001	3	5
OVARY	C2orf15 →	+1.090	+0.244	.005	.003	3	5
LUNG_NSCLC_LUSC	SGCB →	-1.652	-0.400	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070127 vs AIF1L — STOMACH

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