Interleukin-27-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-27-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, SP110_S380, and STAT1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-27-mediated signaling pathway activity versus SAMHD1 in HNSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAMHD1 →	+0.640	+0.134	<.001	<.001	3	10
UCEC	SP110_S380 →	+0.771	+0.179	<.001	<.001	3	10
BRCA	STAT1 →	+0.784	+0.141	<.001	<.001	3	10
LSCC	STAT1_S532 →	+0.840	+0.135	<.001	<.001	3	10
HNSC	STAT2 →	+0.494	+0.134	<.001	<.001	3	10
LSCC	TAPBP →	+0.669	+0.141	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070106 vs SAMHD1 — HNSC

Explore this scatter interactively →