Interleukin-27-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-27-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS3, OAS2, and IFIT3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-27-mediated signaling pathway activity versus OAS3 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OAS3 →	+1.530	+0.597	<.001	.008	3	7
OV	OAS2 →	+1.607	+0.758	<.001	.001	3	7
HNSC	IFIT3 →	+1.755	+0.448	<.001	<.001	3	7
HNSC	IFIT2 →	+1.719	+0.484	<.001	<.001	3	7
LSCC	IRF1 →	+0.539	+0.407	<.001	<.001	3	7
UCEC	IFI6 →	+2.053	+0.310	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070106 vs OAS3 — OV

Explore this scatter interactively →