Interleukin-27-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-27-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMD9, TRMT12, and DPF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMD9 grouped by Interleukin-27-mediated signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PSMD9 →	-0.931	-1.409	.004	.001	3	5
KIDNEY	TRMT12 →	-0.642	-1.494	<.001	<.001	3	4
CNS	DPF1 →	-0.707	-0.854	.002	<.001	3	4
LUNG_SCLC	TSPO →	+1.441	+1.271	.007	.001	2	4
LUNG_SCLC	STAC →	+2.267	+1.329	.006	.003	3	3
LUNG_SCLC	HGH1 →	-0.857	-1.261	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMD9 by Interleukin-27-mediated signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →