Interleukin-27-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-27-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM167B, SEC24A, and RNF207, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-27-mediated signaling pathway activity versus TMEM167B in BLOOD_Leukemia (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM167B →	+0.537	+1.215	.001	<.001	3	5
BLOOD_Lymphoma	SEC24A →	+0.671	+1.093	.005	.001	3	5
BLOOD_Lymphoma	RNF207 →	+2.856	+1.145	<.001	<.001	3	5
BLOOD_Lymphoma	STXBP5 →	+1.401	+1.688	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ZNF519 →	+1.020	+1.567	.009	.001	3	5
SKIN	PHF13 →	+0.591	+1.239	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070106 vs TMEM167B — BLOOD_Leukemia

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