Regulation of interleukin-6-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of interleukin-6-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOBR_S175, ACAP1_T739, and RGS14_S288, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of interleukin-6-mediated signaling pathway activity versus APOBR_S175 in PDAC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	APOBR_S175 →	+0.764	+0.073	<.001	<.001	3	5
LSCC	ACAP1_T739 →	+0.637	+0.098	<.001	<.001	3	5
LSCC	RGS14_S288 →	+0.621	+0.065	.001	<.001	3	5
PDAC	SF3B1_T426 →	+0.428	+0.057	<.001	<.001	3	5
LSCC	STK10 →	+0.296	+0.072	<.001	<.001	3	5
LSCC	TNFAIP8L2 →	+0.307	+0.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070103 vs APOBR_S175 — PDAC

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