Regulation of interleukin-6-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of interleukin-6-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESRP2, POLN, and TSPAN7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of interleukin-6-mediated signaling pathway activity versus ESRP2 in BRCA (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ESRP2 →	-0.608	-0.394	.001	.002	3	4
BRCA	POLN →	-0.304	-0.433	.004	<.001	3	3
GBM	TSPAN7 →	-1.150	-0.416	<.001	.004	3	3
BRCA	SRCIN1 →	-0.923	-0.392	.003	<.001	3	3
BRCA	NPFFR2 →	-0.441	-0.351	.001	.001	3	3
COAD	GJB2 →	+0.537	+0.541	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070103 vs ESRP2 — BRCA

Explore this scatter interactively →