Regulation of interleukin-6-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of interleukin-6-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF711, FUZ, and ADCK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF711 grouped by Regulation of interleukin-6-mediated signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF711 →	-1.025	-1.096	.006	<.001	3	5
KIDNEY	FUZ →	-1.983	-1.241	.002	.006	3	4
KIDNEY	ADCK1 →	-0.945	-1.411	<.001	<.001	3	4
URINARY_TRACT	MAP3K12 →	-1.992	-1.526	.008	.008	3	4
URINARY_TRACT	PHF23 →	-1.579	-1.912	.006	<.001	3	4
CNS	SFPQ →	-0.347	-0.912	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF711 by Regulation of interleukin-6-mediated signaling pathway activity — CNS

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