Regulation of interleukin-6-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of interleukin-6-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRD2, NDRG3, and PLS3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRD2 grouped by Regulation of interleukin-6-mediated signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BRD2 →	-0.282	-0.463	.004	.001	3	2
LUNG_NSCLC_LUAD	NDRG3 →	+0.152	+0.503	.002	.002	3	2
LUNG_NSCLC_LUAD	PLS3 →	-0.155	-0.392	<.001	.003	3	2
LUNG_NSCLC_LUAD	ACSS2 →	+0.128	+0.332	.009	.001	3	2
CNS	ZNF302 →	+0.360	+0.588	.002	.001	3	1
CNS	C11orf45 →	-0.336	-0.588	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRD2 by Regulation of interleukin-6-mediated signaling pathway activity — CNS

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