Regulation of interleukin-6-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of interleukin-6-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL6ST, IPO5, and MGAT1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of interleukin-6-mediated signaling pathway activity versus IL6ST in LUNG_NSCLC_LUAD (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL6ST →	+1.654	+0.537	<.001	<.001	3	9
KIDNEY	IPO5 →	+0.819	+0.485	<.001	<.001	3	2
LUNG_NSCLC_LUAD	MGAT1 →	+1.158	+0.334	<.001	.001	3	2
SKIN	GMPR2 →	-0.944	-0.415	.005	.007	3	2
SKIN	CDK2 →	-1.811	-0.442	.003	.003	3	2
SKIN	SPCS3 →	+0.692	+0.432	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070103 vs IL6ST — LUNG_NSCLC_LUAD

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