Interleukin-6-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-6-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APBB1IP, ARHGAP25, and ARHGAP30, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-6-mediated signaling pathway activity versus APBB1IP in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	APBB1IP →	+0.425	+0.070	<.001	<.001	3	9
LSCC	ARHGAP25 →	+0.545	+0.086	<.001	<.001	3	9
GBM	ARHGAP30 →	+0.577	+0.059	.002	.001	3	9
LSCC	WAS →	+0.460	+0.072	<.001	<.001	3	8
LSCC	BIN2 →	+0.440	+0.059	<.001	<.001	3	8
LSCC	DOCK2 →	+0.545	+0.072	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070102 vs APBB1IP — LSCC

Explore this scatter interactively →