Interleukin-6-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-6-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLRC2, MAP4K4, and PPP2R5C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-6-mediated signaling pathway activity versus KLRC2 in COAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KLRC2 →	+0.564	+0.293	.001	.006	3	4
GBM	MAP4K4 →	-0.293	-0.182	.002	.002	3	4
GBM	PPP2R5C →	-0.318	-0.234	<.001	<.001	3	4
LSCC	ZNF232 →	+0.535	+0.168	.003	.005	3	3
COAD	ODF3L1 →	-0.310	-0.255	.001	.004	3	3
LSCC	ZNF232-AS1 →	+0.450	+0.173	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070102 vs KLRC2 — COAD

Explore this scatter interactively →