Interleukin-6-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-6-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPARG, ARL6, and ZNF407, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPARG grouped by Interleukin-6-mediated signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPARG →	+3.310	+0.699	<.001	.009	3	4
LUNG_SCLC	ARL6 →	-1.161	-1.180	.001	.005	3	3
BREAST	ZNF407 →	-0.444	-0.239	.009	.009	2	4
LARGE_INTESTINE	MFSD9 →	+0.666	+0.365	.006	<.001	3	3
LARGE_INTESTINE	PRR15 →	+2.768	+0.369	<.001	<.001	3	3
LUNG_NSCLC_LUAD	CDON →	-0.921	-0.271	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPARG by Interleukin-6-mediated signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →