Interleukin-6-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-6-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA40, TRPC1, and ARHGEF12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-6-mediated signaling pathway activity versus NAA40 in LARGE_INTESTINE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAA40 →	+0.717	+0.743	<.001	.005	3	4
LARGE_INTESTINE	TRPC1 →	+1.447	+0.685	<.001	.009	3	4
LARGE_INTESTINE	ARHGEF12 →	+1.046	+0.743	<.001	.006	3	4
LARGE_INTESTINE	MIR1915HG →	+1.558	+0.577	<.001	.005	3	4
LIVER	HEATR6 →	+0.964	+0.287	.009	.007	3	4
LUNG_NSCLC_LUAD	DNM3 →	+1.243	+0.549	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070102 vs NAA40 — LARGE_INTESTINE

Explore this scatter interactively →