Negative regulation of chemokine-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of chemokine-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN7, STAB1, and WAS, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine-mediated signaling pathway activity versus PTPN7 in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTPN7 →	+0.482	+0.066	.002	.006	3	9
GBM	STAB1 →	+0.568	+0.109	<.001	<.001	3	8
GBM	WAS →	+0.706	+0.106	<.001	<.001	3	8
GBM	TBC1D2B →	+0.347	+0.097	<.001	<.001	3	8
LSCC	CORO1A →	+0.425	+0.078	<.001	<.001	3	8
GBM	IL16 →	+0.618	+0.111	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070100 vs PTPN7 — CCRCC

Explore this scatter interactively →