Negative regulation of chemokine-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of chemokine-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI30, KLHL41, and ZNF19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine-mediated signaling pathway activity versus IFI30 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFI30 →	+0.431	+0.490	.001	.004	3	4
GBM	KLHL41 →	-0.379	-0.588	<.001	.005	3	4
BRCA	ZNF19 →	-0.252	-0.544	.008	.002	3	3
BRCA	OSCAR →	+0.523	+0.426	.007	.007	3	3
BRCA	C12orf66 →	-0.443	-0.656	<.001	<.001	3	3
BRCA	ERCC4 →	-0.443	-0.441	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070100 vs IFI30 — BRCA

Explore this scatter interactively →