Negative regulation of chemokine-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELP4, PBK, and CNOT8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELP4 grouped by Negative regulation of chemokine-mediated signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ELP4 →	-0.253	-2.232	.002	<.001	3	3
CNS	PBK →	+0.206	+2.126	.004	.003	3	3
SKIN	CNOT8 →	+0.210	+1.641	.002	<.001	3	3
LUNG_NSCLC_LUAD	FAM157B →	-0.395	-2.258	.005	.001	3	2
LUNG_SCLC	ARPP19 →	-0.188	-1.437	<.001	.005	3	2
LUNG_SCLC	FOXP4 →	+0.182	+1.683	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELP4 by Negative regulation of chemokine-mediated signaling pathway activity — CNS

Explore this box plot interactively →