Negative regulation of chemokine-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WBP4, PRMT3, and GDPD5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine-mediated signaling pathway activity versus WBP4 in STOMACH (Pearson r = -0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WBP4 →	-0.660	-2.017	.004	.002	3	3
STOMACH	PRMT3 →	-1.126	-2.017	.001	.002	3	3
BREAST	GDPD5 →	+2.535	+1.403	.009	.007	3	3
BREAST	ATP2C2 →	+3.895	+1.403	<.001	.007	3	3
LUNG_SCLC	DHX35 →	-0.448	-1.083	.006	.001	3	3
LUNG_SCLC	TRADD →	+1.076	+1.186	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070100 vs WBP4 — STOMACH

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