Regulation of chemokine-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of chemokine-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A4, DAB2, and STK10_S514, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chemokine-mediated signaling pathway activity versus S100A4 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A4 →	+0.722	+0.093	<.001	<.001	3	8
LSCC	DAB2 →	+0.410	+0.087	<.001	<.001	3	8
OV	STK10_S514 →	+0.977	+0.067	.001	.001	3	8
OV	DOCK10 →	+0.443	+0.095	.001	<.001	3	8
OV	GGT5 →	+0.779	+0.092	<.001	<.001	3	8
UCEC	ANKRD44 →	+0.321	+0.075	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070099 vs S100A4 — BRCA

Explore this scatter interactively →