Regulation of chemokine-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of chemokine-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGHG3, IGKJ3, and KRT18P39, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chemokine-mediated signaling pathway activity versus IGHG3 in UCEC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHG3 →	+1.478	+0.526	.001	.004	3	5
LUAD	IGKJ3 →	+1.073	+0.387	.001	.002	3	4
CCRCC	KRT18P39 →	+0.164	+0.359	.002	.006	3	4
CCRCC	PADI2 →	+0.751	+0.527	<.001	.001	3	3
HNSC	PLCB4 →	+1.161	+0.602	.001	.003	3	3
OV	IL2RB →	+0.720	+0.625	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070099 vs IGHG3 — UCEC

Explore this scatter interactively →