Regulation of glucagon secretion

Across TCGA patient cohorts, RNA activity of the Regulation of glucagon secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67_S2528, RACGAP1_S203, and SYT7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucagon secretion activity versus MKI67_S2528 in LUAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MKI67_S2528 →	+0.971	+0.110	.001	<.001	3	5
LUAD	RACGAP1_S203 →	+0.897	+0.122	.001	<.001	3	5
HNSC	SYT7 →	+1.032	+0.170	<.001	<.001	3	4
LSCC	USP6NL →	-0.259	-0.102	.003	<.001	3	4
LUAD	CAMP →	+0.944	+0.093	<.001	<.001	3	4
LSCC	FCN2 →	+0.352	+0.078	.008	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070092 vs MKI67_S2528 — LUAD

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