Regulation of glucagon secretion

Across TCGA patient cohorts, RNA activity of the Regulation of glucagon secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHGB_S149, NDRG4_S298, and ROCK2_S1134, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucagon secretion activity versus CHGB_S149 in BRCA (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHGB_S149 →	+2.743	+0.364	<.001	<.001	3	3
PDAC	NDRG4_S298 →	+0.719	+0.939	<.001	.001	3	3
LUAD	ROCK2_S1134 →	+0.771	+0.962	<.001	<.001	3	3
BRCA	CHGB_S405 →	+3.382	+0.336	<.001	<.001	3	3
GBM	SEC61A1 →	-0.329	-0.697	.001	.001	3	2
BRCA	SNW1_S232 →	-0.965	-0.447	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070092 vs CHGB_S149 — BRCA

Explore this scatter interactively →