Ubiquitin-dependent endocytosis

Across TCGA patient cohorts, RNA activity of the Ubiquitin-dependent endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP14A, FLI1, and SYK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent endocytosis activity versus UTP14A in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UTP14A →	-0.283	-0.065	.004	<.001	3	5
UCEC	FLI1 →	+0.292	+0.064	.003	.002	3	5
GBM	SYK →	+0.507	+0.060	<.001	.002	3	5
GBM	EPB41L3 →	+0.411	+0.057	.004	.001	3	5
COAD	OTULINL →	+0.458	+0.044	.001	.002	3	4
UCEC	INPP5D_S971 →	+0.633	+0.060	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070086 vs UTP14A — OV

Explore this scatter interactively →