Ubiquitin-dependent endocytosis

Across TCGA patient cohorts, RNA activity of the Ubiquitin-dependent endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP12P2, ZNF847P, and ABI1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent endocytosis activity versus THAP12P2 in PDAC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	THAP12P2 →	-0.146	-0.762	.005	.001	3	3
HNSC	ZNF847P →	+0.333	+0.543	.003	.001	3	3
GBM	ABI1 →	+0.438	+0.512	.002	.004	3	2
GBM	CEP295NL →	-0.433	-0.561	.001	<.001	3	2
GBM	EEF1A1P41 →	-0.352	-0.601	<.001	<.001	3	2
GBM	MPPE1P1 →	-0.203	-0.468	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070086 vs THAP12P2 — PDAC

Explore this scatter interactively →