Ubiquitin-dependent endocytosis

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPKC, C2orf15, and PPP1R13L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent endocytosis activity versus ITPKC in URINARY_TRACT (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ITPKC →	-1.942	-0.532	.001	<.001	3	4
URINARY_TRACT	C2orf15 →	-2.100	-0.642	.006	<.001	3	3
BREAST	PPP1R13L →	-1.049	-0.225	<.001	.006	3	3
BREAST	MICU1 →	+0.754	+0.339	.004	.004	3	3
BREAST	TNFSF10 →	-2.896	-0.294	.006	.003	3	3
BREAST	CRABP2 →	-2.845	-0.271	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070086 vs ITPKC — URINARY_TRACT

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