Glycosylation

pathway activity — cross-omics
GO:0070085Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glycosylation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD55, SRRM2_S1112, and TAF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADCD55 →+0.588+0.011<.001.00135
BRCASRRM2_S1112 →-0.852-0.022<.001<.00135
GBMTAF2 →-0.225-0.021.002.00235
GBMVIRMA →-0.158-0.022<.001<.00135
GBMCNRIP1 →+0.437+0.021.004.00535
BRCAFAM114A1 →+0.391+0.013<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration