Glycosylation

pathway activity — cross-omics
GO:0070085Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCF11, RPL26P6, and PPIAP67, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMPCF11 →-0.378-0.213<.001<.00136
LUADRPL26P6 →-0.252-0.138.005<.00135
HNSCPPIAP67 →-0.898-0.163<.001.00135
CCRCCPPP1R16B →-0.570-0.227.002.00335
CCRCCFHL5 →-0.840-0.176<.001<.00135
OVBBS10 →-0.404-0.172.003.00535
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration