Vacuolar proton-transporting V-type ATPase complex assembly

Across TCGA patient cohorts, RNA activity of the Vacuolar proton-transporting V-type ATPase complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF462_S1747, CDK18_S89, and UTP18_S205, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuolar proton-transporting V-type ATPase complex assembly activity versus ZNF462_S1747 in GBM (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF462_S1747 →	-0.920	-0.064	<.001	<.001	3	5
GBM	CDK18_S89 →	+0.890	+0.049	<.001	.003	3	5
PDAC	UTP18_S205 →	-0.532	-0.075	<.001	.002	3	5
LUAD	COBLL1_S326 →	+0.696	+0.059	<.001	<.001	3	5
LSCC	SRSF1_S199 →	-0.322	-0.054	.001	.003	3	5
LUAD	VPS13C_S3484 →	+1.077	+0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070072 vs ZNF462_S1747 — GBM

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