Vacuolar proton-transporting V-type ATPase complex assembly

Across TCGA patient cohorts, RNA activity of the Vacuolar proton-transporting V-type ATPase complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP206, ANK3-DT, and LINC01116, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuolar proton-transporting V-type ATPase complex assembly activity versus CFAP206 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CFAP206 →	+0.170	+0.129	.001	<.001	3	4
HNSC	ANK3-DT →	-0.411	-0.187	.005	<.001	3	4
BRCA	LINC01116 →	+0.927	+0.118	<.001	<.001	3	4
UCEC	NEK5 →	+0.898	+0.144	<.001	<.001	3	4
BRCA	FEZ2 →	+0.300	+0.095	<.001	.005	3	3
HNSC	SRRM2 →	-0.617	-0.123	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070072 vs CFAP206 — GBM

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