Vacuolar proton-transporting V-type ATPase complex assembly

Across TCGA cell cohorts, RNA activity of the Vacuolar proton-transporting V-type ATPase complex assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDOB, TM9SF4, and ATP6V1B1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDOB grouped by Vacuolar proton-transporting V-type ATPase complex assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ALDOB →	-0.293	-1.927	<.001	<.001	3	10
LARGE_INTESTINE	TM9SF4 →	-0.263	-1.328	.001	.001	3	9
CNS	ATP6V1B1 →	-0.154	-0.730	.003	.002	2	7
LUNG_NSCLC_LUAD	VMA21 →	-0.368	-1.120	.005	.002	3	6
CNS	TMEM199 →	-0.224	-0.975	.009	.009	1	8
PANCREAS	HOXB8 →	-0.212	-1.161	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDOB by Vacuolar proton-transporting V-type ATPase complex assembly activity — OESOPHAGUS

Explore this box plot interactively →